In Opportunity Knocks Twice, George Valentine receives a frantic call from Greta Jenkins, the housekeeper of Abel Merton, who is worried about his nephew, Larry. Larry is in a drunken state, and Greta fears he might harm himself following the death of his uncle, which is being treated as a suicide. As George arrives at the scene, he learns that Larry has a note with George's name in his pocket, indicating he intended to seek help. The situation escalates when Larry claims he is responsible for his uncle's death, leading George to question the validity of the suicide ruling.