In Clouds Across the Moon, the Lone Ranger finds himself embroiled in a dangerous plot against the construction of the transcontinental railroad, a vital project for the future of the American West. The Iron Spur gang, intent on sabotaging this progress, disguises themselves as Cheyenne Indians to instill fear among the railroad workers. As the construction crew pushes further into the plains, they become increasingly anxious about the perceived threat from the Indians, unaware that they are being manipulated by the gang.