In The Killer Cards, the story begins with Nero Wolfe being approached by a man named Denby, who insists that Wolfe preside over a poker game with high stakes. Wolfe, known for his aversion to leaving his home and his disdain for card games, flatly refuses the offer. However, Denby reveals that the game is not just for fun; it is a deadly contest among four co-owners of the Candy Club, a gambling establishment, where the winner takes all. The tension is palpable as Denby hints that one of the players may end up dead.