In The John Nelson Murder Case, Detective Danny Clover arrives at the Ruxton Hotel to investigate the shocking murder of John Nelson, who is found stabbed in his neat hotel room. The scene is set against the vibrant backdrop of Broadway, where the atmosphere is filled with both romance and danger. Clover learns from Detective Muggerman that Nelson had been living at the hotel for several years and was known to be a quiet man. However, the peculiarities of his life raise questions, especially regarding his financial situation and the strange assortment of wildlife pictures decorating his walls.